Starting a new medication always brings questions, and for plenty of people on Mounjaro (tirzepatide), one of the most pressing ones has everything to do with the bathroom. Constipation shows up in a large portion of users – especially in those early weeks – and if you’re dealing with it right now, you’re probably desperate to know when it’ll stop. Short answer: most people see it ease within two to four weeks of each dose level, though some notice changes in bowel habits for as long as they stay on the medication or step up their dose. How long it actually sticks around depends on your dosage, your diet, your hydration, and how your particular gut responds to tirzepatide. Knowing the mechanism behind it makes the timeline far easier to read and gives you a clearer sense of what’s normal versus what genuinely needs a doctor’s attention.